Importance of Relating Efficacy Measures to Unbound Drug Concentrations for Anti-Infective Agents
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چکیده
منابع مشابه
Optimal Anti-infective Drug Doses for Children
OPTIMAL ANTI-INFECTIVE DRUG DOSES FOR CHILDREN Anti-infective agents are among the most commonly prescribed drugs in children. What is considered the optimal dose of an anti-infective agent is determined by how the child handles the drug and the resulting drug concentration in the body (pharmacokinetics, PK) as well as by the effect of the drug on the target pathogen (pharmacodynamics, PD). Amo...
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BACKGROUND Area under the concentration-time curve (AUC) is a pharmacokinetic parameter that represents overall exposure to a drug. For selected anti-infective agents, pharmacokinetic-pharmacodynamic parameters, such as AUC/MIC (where MIC is the minimal inhibitory concentration), have been correlated with outcome in a few studies. A limited-sampling strategy may be used to estimate pharmacokine...
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ژورنال
عنوان ژورنال: Clinical Microbiology Reviews
سال: 2013
ISSN: 0893-8512,1098-6618
DOI: 10.1128/cmr.00092-12